Title | Calreticulin exposure orchestrates innate immunosurveillance. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Guilbaud E, Kroemer G, Galluzzi L |
Journal | Cancer Cell |
Volume | 41 |
Issue | 6 |
Pagination | 1014-1016 |
Date Published | 2023 Jun 12 |
ISSN | 1878-3686 |
Keywords | Calreticulin, Humans, Monitoring, Immunologic, Mutation, Myeloid Cells, Phagocytes |
Abstract | Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance. |
DOI | 10.1016/j.ccell.2023.04.015 |
Alternate Journal | Cancer Cell |
PubMed ID | 37207656 |