| Title | Epigenetic escape of immunosurveillance by malignant cell precursors. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Galassi C, Galluzzi L |
| Journal | EMBO J |
| Volume | 42 |
| Issue | 10 |
| Pagination | e114050 |
| Date Published | 2023 May 15 |
| ISSN | 1460-2075 |
| Keywords | Epigenomics, Humans, Immunologic Surveillance, Immunotherapy, Monitoring, Immunologic, Neoplasms, Tumor Escape |
| Abstract | Newly formed malignant cells must escape immunosurveillance to generate progressing neoplastic lesions of clinical relevance. Recent data indicate that the immunogenicity of nascent cancer cells, at least in some settings, is dictated by inherent epigenetic mechanisms rather than by immunoediting and the consequent Darwinian selection of poorly immunogenic phenotypes. |
| DOI | 10.15252/embj.2023114050 |
| Alternate Journal | EMBO J |
| PubMed ID | 37051718 |
| PubMed Central ID | PMC10183812 |