Town Hall | Englander Institute for Precision Medicine
Join us for updates on initiatives at the Englander Institute for Precision Medicine.
Whole-genome Sequencing of de novo Small Cell Prostate Cancer and CRPC: Molecular Tumor Board
Patients referred by Drs. Cora N. Sternberg, Ana M. Molina and David Nanus
Cases presented by
Majd Al Assaad, M.D.
Senior Research Fellow
Department of Pathology and Laboratory Medicine
and Englander Institute for Precision Medicine
Weill Cornell Medicine
The ICGC project is pan-cancer with all major cancer types represented as well as less frequent tumour types including paediatric tumours. By combining genomic data with circulating tumour analysis, transcriptomic data and organoid model development we aim to utilize a multi- faceted approach to better understand the molecular roots of cancer.
Englander Institute for Precision Medicine Members participating in this event include Director Olivier Elemento, and Drs. Cora Sternberg, Andrea Sboner, Wei Song, Massimo Cristofanilli, Pashtoon Kasi, Bishoy Faltas, and Juan Miguel Mosquera.
EIPM Director Olivier Elemento, Ph.D. will present "From whole genomes to patient avatars - the future of personalized medicine for cancer patients," during the session "Tumor Organoid Models for Predictive Therapeutics," at 12:05 pm on Tuesday, October 24th.
The WCM Cell and Cancer Pathobiology Symposium, featuring current and former EIPM colleagues Drs. Himisha Beltran, Ekta Khurana, and David Rickman, is a new series of two-day meetings on fundamental questions on the biology and pathology of cancer. The goal is to create a discussion-friendly type of conference, restricted to about 100-120 participants, in which interactions among speakers and attendees will spark new ideas and potential collaborations. An interactive environment is key for the success of this type of symposia.
This first symposium was focused on the metabolism of cancer and the inflammatory response that either drives tumor initiation or favors the creation of tissue microenvironments conducive to tumorigenesis and metastatic spread. Inflammation and the immune response are hot areas of research in cancer and are producing new therapies that, by harnessing the immune system's power, hold the promise of a cure or at least better treatments.
This second symposium will focus on the processes controlling cell plasticity and differentiation in epithelial cancer cells and their surrounding stroma and on how the crosstalk between these two types of cells impacts the tumor microenvironment. The acquisition of a plastic phenotype is linked to developmental processes of cell reprogramming in response to injury and inflammation and during therapy resistance. Examples of these mechanisms include the metaplasia of epithelial cells during acute and chronic inflammation or the acquisition of small-cell carcinoma/neuroendocrine lineages in different cancers in response to therapy resistance. The stroma fibroblast compartment is also reprogrammed in response to epithelial cues. It is becoming progressively apparent that the fibroblast’s signaling back to the tumor epithelium impinges on its plasticity and mesenchymal features. A more complete understanding of the molecular and cellular interactions governing these processes is key for identifying new vulnerabilities potentially targetable therapeutically. These critical questions in cancer research will be presented and discussed in a very interactive environment.
Please help spread the word! Our friends from
and
will present a free prostate cancer screening (PSA blood test, family history) a week from today! #prostatecancer Email for more info: WCMUrologyEvents@med.cornel.edu
Don't miss the next @WCM_MeyerCancer Collaborative Research Initiative mini-symposium and hear from @WCMEnglanderIPM Members like Director Olivier Elemento, PhD (@ElementoLab), @RickmanLab, @niroanandalab and Dr. Rohit Chandwani!
EIPM Seminar Series lecture “#Metabolomic Biomarker Profiling for Multi-Disease Prediction in Large Biobanks – Molecular Insights to Advancing Preventative Health Screening," will be presented by Dr. Peter Würtz, founder @NgaleHealth
