| Title | BAX and BAK dynamics control mitochondrial DNA release during apoptosis. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Yamazaki T, Galluzzi L |
| Journal | Cell Death Differ |
| Volume | 29 |
| Issue | 6 |
| Pagination | 1296-1298 |
| Date Published | 2022 Jun |
| ISSN | 1476-5403 |
| Keywords | Apoptosis, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, DNA, Mitochondrial, Mitochondria |
| Abstract | BAX and BAK are generally considered as fully interchangeable for mitochondrial permeabilization and consequent apoptotic cell death. Garcia-Saez and colleagues have recently documented striking kinetic differences that influence BAX and BAK oligomerization at the mitochondrial surface. These data have important implications for inflammatory responses driven by mitochondrial DNA. |
| DOI | 10.1038/s41418-022-00985-2 |
| Alternate Journal | Cell Death Differ |
| PubMed ID | 35347233 |
| PubMed Central ID | PMC9177580 |