| Title | Calreticulin surface presentation can promote quality control of hematopoietic stem cells. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Galluzzi L, Kroemer G |
| Journal | Trends Immunol |
| Volume | 43 |
| Issue | 12 |
| Pagination | 950-952 |
| Date Published | 2022 Dec |
| ISSN | 1471-4981 |
| Keywords | Animals, Calreticulin, Hematopoiesis, Hematopoietic Stem Cells, Mice, Zebrafish |
| Abstract | Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis. |
| DOI | 10.1016/j.it.2022.10.008 |
| Alternate Journal | Trends Immunol |
| PubMed ID | 36307308 |
| Grant List | U54 CA274291 / CA / NCI NIH HHS / United States |