| Title | Catastrophic DNA replication in unscheduled tetraploid cells. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Manic G, Galluzzi L, Vitale I |
| Journal | Trends Genet |
| Volume | 38 |
| Issue | 8 |
| Pagination | 787-788 |
| Date Published | 2022 Aug |
| ISSN | 0168-9525 |
| Keywords | Aneuploidy, Cell Cycle Proteins, DNA Replication, Humans, Mitosis, S Phase, Tetraploidy |
| Abstract | Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations. |
| DOI | 10.1016/j.tig.2022.04.005 |
| Alternate Journal | Trends Genet |
| PubMed ID | 35490031 |