| Title | Ectopic Myoglobin Expression Is Associated with a Favourable Outcome in Head and Neck Squamous Cell Carcinoma Patients. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Meller S, VAN Ellen A, Gevensleben H, Bicker A, Hankeln T, Gorr TA, Sailer V, Dröge F, Schröck F, Bootz F, Schröck A, Perner S, Dietrich D, Kristiansen G |
| Journal | Anticancer Res |
| Volume | 36 |
| Issue | 12 |
| Pagination | 6235-6241 |
| Date Published | 2016 Dec |
| ISSN | 1791-7530 |
| Keywords | Adolescent, Adult, Carcinoma, Squamous Cell, Child, Child, Preschool, Female, Head and Neck Neoplasms, Humans, Infant, Infant, Newborn, Male, Middle Aged, Myoglobin, Treatment Outcome, Young Adult |
| Abstract | BACKGROUND/AIM: Ectopic myoglobin (MB) expression, mediated by alternative and hypoxia-inducible transcription, has recently been demonstrated in several epithelial tumours. This study aimed to examine the expression of MB in hormone-independent head and neck squamous cell carcinomas (HNSCCs). PATIENTS AND METHODS: Using imunohistochemistry, ectopic MB expression was analyzed on tissue microarrays (TMAs) of 524 patients with localized and locally advanced primary and recurrent HNSCC who had undergone surgical treatment with curative intent. Associations of MB expression with survival and clinicopathological parameters were analyzed. RESULTS: MB expression was found in 45.8% of HNSCC patients being significantly lower in normal adjacent tissue (NAT) compared to primary and recurrent tumours (p<0.001) and significantly associated with a favourable overall survival (OS) in HNSCC [p=0.037, hazard ratio (HR)=0.72, 95% confidence interval (CI)=0.53-0.98]. Furthermore, MB expression negatively correlated with human papillomavirus (HPV) status (p=0.013). CONCLUSION: MB is differentially expressed in HNSCC and correlates with a better OS. |
| DOI | 10.21873/anticanres.11217 |
| Alternate Journal | Anticancer Res |
| PubMed ID | 27919941 |