Title | Immunogenic cell death in cancer: concept and therapeutic implications. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Galluzzi L, Kepp O, Hett E, Kroemer G, Marincola FM |
Journal | J Transl Med |
Volume | 21 |
Issue | 1 |
Pagination | 162 |
Date Published | 2023 Mar 02 |
ISSN | 1479-5876 |
Keywords | Animals, Cell Death, Cell Differentiation, Homeostasis, Immunogenic Cell Death, Mammals, Neoplasms |
Abstract | Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy. |
DOI | 10.1186/s12967-023-04017-6 |
Alternate Journal | J Transl Med |
PubMed ID | 36864446 |
PubMed Central ID | PMC9979428 |
Grant List | U54 CA274291 / CA / NCI NIH HHS / United States |