| Title | p53 regulates the mitochondrial immune checkpoint. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Vanpouille-Box C, Galluzzi L |
| Journal | Trends Immunol |
| Volume | 44 |
| Issue | 4 |
| Pagination | 245-247 |
| Date Published | 2023 Apr |
| ISSN | 1471-4981 |
| Keywords | Apoptosis, DNA, Mitochondrial, Humans, Mitochondria, Tumor Suppressor Protein p53 |
| Abstract | Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing. |
| DOI | 10.1016/j.it.2023.03.001 |
| Alternate Journal | Trends Immunol |
| PubMed ID | 36933950 |
| Grant List | U54 CA274291 / CA / NCI NIH HHS / United States |