| Title | T cell-independent abscopal responses to radiotherapy. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Guilbaud E, Yamazaki T, Galluzzi L |
| Journal | Trends Cancer |
| Volume | 9 |
| Issue | 2 |
| Pagination | 93-95 |
| Date Published | 2023 Feb |
| ISSN | 2405-8025 |
| Keywords | CD8-Positive T-Lymphocytes, Dose Fractionation, Radiation, Humans, Neoplasms |
| Abstract | When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an 'abscopal' response independent of CD8 T cells. |
| DOI | 10.1016/j.trecan.2022.12.005 |
| Alternate Journal | Trends Cancer |
| PubMed ID | 36543690 |
| Grant List | U54 CA274291 / CA / NCI NIH HHS / United States |